tert-Butyl 4-aminoazepane-1-carboxylate → HCID 135921461, compound

HRID 2189222Notes

Reaction equation

HRID 2189222 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[C:4]([C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=2[O:19]C)[N:3]=1.C(OC(N1CCCCC(N)C1)=O)(C)(C)C.C(OC([N:43]1[CH2:49][CH2:48][CH2:47][CH:46]([NH2:50])[CH2:45][CH2:44]1)=O)(C)(C)C>>[NH:43]1[CH2:49][CH2:48][CH2:47][CH:46]([NH:50][C:2]2[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[N:5]=[C:4]([C:12]3[CH:17]=[C:16]([F:18])[CH:15]=[CH:14][C:13]=3[OH:19])[N:3]=2)[CH2:45][CH2:44]1

Participants

4

Reactant 3

HCID 18946151tert-Butyl 4-aminoazepane-1-carboxylateHCID 23068067tert-Butyl 3-aminoazepane-1-carboxylateHCID 86656547HCID 86656547, compound

Product 1

HCID 135921461HCID 135921461, compound

Procedure

The title compound was prepared using a method analogous to that described in Synthesis 52, replacing 4-chloro-2-(2-methoxyphenyl)quinazoline with 4-chloro-2-(5-fluoro-2-methoxyphenyl)quinazoline in Synthesis 52-A and tert-butyl-3-aminoazepane-1-carboxylate with tert-butyl-4-aminoazepane-1-carboxylate in Synthesis 52-B.

Workup

  1. customthat described in Synthesis 52

Sources & evidence

ORD record
ord-5cc0a6df5edb4a95b153c9c08dda7c25
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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