2-Methoxybenzoyl chloride → HCID 136068466, compound

HRID 2189223Notes

Reaction equation

HRID 2189223 reaction equation
C[O:2][C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[C:5](Cl)=O.[NH2:12][C:13]1[CH:20]=[C:19]([Br:21])[CH:18]=[CH:17][C:14]=1[C:15]#[N:16].[C:22]([O:26][C:27]([N:29]1[CH2:34][CH2:33]C[C@H:31]([NH2:35])[CH2:30]1)=[O:28])([CH3:25])([CH3:24])[CH3:23]>>[Br:21][C:19]1[CH:20]=[C:13]2[C:14]([C:15]([NH:35][C@H:31]3[CH2:33][CH2:34][N:29]([C:27]([O:26][C:22]([CH3:23])([CH3:24])[CH3:25])=[O:28])[CH2:30]3)=[N:16][C:5]([C:4]3[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=3[OH:2])=[N:12]2)=[CH:17][CH:18]=1

Participants

4

Reactant 3

HCID 889692-Methoxybenzoyl chlorideHCID 1501975tert-butyl (3S)-3-aminopiperidine-1-carboxylateHCID 99206362-Amino-4-bromobenzonitrile

Product 1

HCID 136068466HCID 136068466, compound

Procedure

The title compound was prepared from 2-methoxybenzoyl chloride, 2-amino-4-bromobenzonitrile and (S)-3-amino-piperidine-1-carboxylic acid tert-butyl ester using methods analogous to those described in Synthesis 1, steps 1-A, 2-B and 1-D.

Sources & evidence

ORD record
ord-deff8ca4a6a845f09c6f59ef8b7a7bc3
Source dataset
uspto-grants-2012_12
Patent number
US08324226B2

Reaction notes

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