HCID 67367212, compound → HCID 67365517, compound

Participants

Reaction Steps

trans-1-Benzyl-3-(4-methoxyphenyl)-4-nitropyrrolidine (0.205 g, 0.66 mmol) was dissolved in methanol (10 mL) and hydrogenated under a hydrogen atmosphere at atmospheric pressure in the presence of Raney nickel (˜8 mL). After stirring for 2 h the solution was concentrated in vacuo and purified by ion exchange chromatography on SCX-2 (solute acidic resin (2 g), eluting with methanol and then 1 M ammonia in methanol to give the title compound (0.116 g, 62%) as a colourless oil that was used without further purification.

Provenance & Evidence