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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189241Generated: October 31, 2026

2-Methyl-3-butyn-2-ol → HCID 136068498, compound

https://huagongshe.com/reaction/2189241

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Methyl-3-butyn-2-olHCID 8258—
ReactantHCID 136068452HCID 136068452—
ReactantHCID 136068485HCID 136068485—
ReactantHCID 136337398HCID 136337398—
ProductHCID 136068498HCID 136068498—

Reaction Steps

The title compound was prepared using a method analogous to that described in Synthesis 59, replacing propargyl alcohol and (S)-tert-butyl 3-(6-bromo-2-(2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate with dimethyl propargyl alcohol and (S)-tert-butyl 3-(6-bromo-2-(5-fluoro-2-hydroxyphenyl)quinazolin-4-ylamino)pyrrolidine-1-carboxylate in Synthesis 59-A.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324226B2
Source datasetuspto-grants-2012_12
ORD IDord-862a69939c84441d8507222a1d8017e2
Source noteuspto-grants-2012_12