3-Pentanamine → HCID 58015804, compound

Participants

Reaction Steps

To a solution of 2,4-dichloro-5-nitro-pyrimidine (2 g, 10.31 mmol) in anhydrous EtOH (20 ml) is added 1-ethylpropylamine (1.322 ml, 11.341 mmol) at 0 C (ice bath) under inert atmosphere. To this is added neat DIPEA (2.694 ml, 15.465 mmol). The reaction is stirred at r.t. for 8 hrs. The reaction mixture was concentrated in vacuo and the residue is dissolved with EtOAc. The organic layer is washed with sat. NaHCO3 and brine, dried over Na2SO4, and concentrated in vacuo. Purification with column chromatography (SiO2, 1:3 EtOAC/Hexane) gives the desired product.

Provenance & Evidence