Dimethylformamide → HCID 58015786, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial is added the crude (2-Chloro-5-amino-pyrimidin-4-yl)-(1-ethyl-propyl)-amine (0.5 g, 2.329 mmol) and anhydrous DMF (15 ml) followed by 1,1′-carbonyldiimidazole (1.133 g, 6.987 mmol). Sealed vial and microwave heated at 100° C. for 10 min. The reaction mixture is diluted with EtOAc, washed with water, dried over Na2SO4, and concentrated in vacuo. Purification with column chromatography (SiO2, 1:1 EtOAC/Hexane) gives the desired product.

Provenance & Evidence