Diisopropylethylamine → HCID 58016012, compound

Participants

Reaction Steps

To a solution of allyl-(1-ethyl-propyl)-amine (10 mmol) is added anhydrous isopropanol (50 ml) and 5-bromo-2,4-dichloropyrimidine (2.979 g, 5 mmol) followed by diisopropylethylamine (2.61 ml, 15 mmol) at ambient temperature. The reaction is stirred overnight and concentrated in vacuo. The residue is purified with column chromatography (SiO2, 1:5 EtOAC/Hexane) to give the desired product.

Provenance & Evidence