Triethylamine → HCID 58015762, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of allyl-(5-bromo-2-chloro-pyrimidin-4-yl)-(1-ethyl-propyl)-amine (2.76 g, 8.7 mmol) in anhydrous DMF (15 ml) was added 8 mol % of Pd(OAc)2 (156 mg, 0.69 mmol) and 8 mol % of PPh3 (182 mg, 0.69 mmol) and triethylamine (2.4 ml, 17.3 mmol) a The reaction is stirred at 100° C. overnight. The reaction mixture is diluted with EtOAc, washed with water, dried over Na2SO4, and concentrated in vacuo. Purification with column chromatography (SiO2, 1:2 EtOAC/Hexane) gives the desired product.

Provenance & Evidence