Hydrochloric Acid → HCID 23624284, compound

Participants

Reaction Steps

To a solution 1-(4-{4-[6-Diethoxymethyl-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-piperazin-1-yl)-ethanone (178 mg, 0.35 mmol) in 1,4 dioxane (2.8 mL) is added 0.8 mL of concentrated HCl at ambient temperature. The reaction mixture is stirred at ambient temperature for 30 mins. The mixture is neutralized with 1 N NaOH aqueous solution and saturated NaHCO3 aqueous solution, extracted with EtOAc. The organic layer is washed with brine, dried Na2SO4, and concentrated under reduced pressure to give 160 mg of the title compound as a yellow solid.

Provenance & Evidence