2-Chloropropane → 2-Chloro-7-cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

HRID 2189304Notes

Reaction equation

HRID 2189304 reaction equation
[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[CH:10]=[CH:9][N:8]([CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)[C:6]=2[N:7]=1.Cl[CH:17]([CH3:19])[CH3:18].ClC1N=CC2C(C(=O)C)=CN(C3CCCC3)C=2N=1>>[Cl:1][C:2]1[N:3]=[CH:4][C:5]2[C:10]([CH:17]([CH3:19])[CH3:18])=[CH:9][N:8]([CH:11]3[CH2:15][CH2:14][CH2:13][CH2:12]3)[C:6]=2[N:7]=1

Participants

4

Reactant 3

HCID 63612-ChloropropaneHCID 866373422-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidineHCID 866373431-(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethanone

Product 1

HCID 848198052-Chloro-7-cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidine

Procedure

2-Chloro-7-cyclopentyl-5-isopropyl-7H-pyrrolo[2,3-d]pyrimidine is prepared from 2-chloro-7-(cyclopentyl)-7H-pyrrolo[2,3-d]pyrimidine and 2-chloropropane using a method similar to that for the preparation of 1-(2-Chloro-7-cyclopentyl-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-ethanone given in Example 325.

Sources & evidence

ORD record
ord-e286ec7a2ceb4530b426a3384e8a65e4
Source dataset
uspto-grants-2012_12
Patent number
US08324225B2

Reaction notes

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