N-(2-aminoethyl)acetamide → N-(2-Acetylamino-ethyl)-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide

HRID 218931Notes

Reaction equation

HRID 218931 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([I:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]1[CH:18]=[N:17][CH:16]=[CH:15][C:11]=1[C:12]([OH:14])=O.[NH2:19][CH2:20][CH2:21][NH:22][C:23](=[O:25])[CH3:24]>>[C:23]([NH:22][CH2:21][CH2:20][NH:19][C:12](=[O:14])[C:11]1[CH:15]=[CH:16][N:17]=[CH:18][C:10]=1[NH:9][C:3]1[CH:4]=[CH:5][C:6]([I:8])=[CH:7][C:2]=1[Cl:1])(=[O:25])[CH3:24]

Participants

3

Reactant 2

HCID 66082N-(2-aminoethyl)acetamideHCID 576496513-[(2-Chloro-4-iodophenyl)amino]isonicotinic acid2×

Product 1

HCID 11510885N-(2-Acetylamino-ethyl)-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide

Procedure

N-(2-Acetylamino-ethyl)-3-(2-chloro-4-iodo-phenylamino)-isonicotinamide was synthesized according to the procedure for General Method 1, outlined above, starting with 0.32 mmol of 3-[(2-chloro-4-iodophenyl)amino]isonicotinic acid (intermediate 2) and 0.44 mmol N-(2-amino-ethyl)-acetamide LC/MS [8.38 min; 4.59 (M+1)]

Sources & evidence

ORD record
ord-361bc0d1c33d422dbeeca537f66545d4
Source dataset
uspto-grants-2012_06
Patent number
US08198457B2

Reaction notes

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