Hydrochloric Acid → HCID 23624284, compound

Participants

Reaction Steps

To a solution 1-(4-{4-[6-diethoxymethyl-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino]-phenyl}-piperazin-1-yl)-ethanone (0.178 g, 0.35 mmol) in 1,4 dioxane (2.8 mL) is added 0.8 mL of concentrated HCl at ambient temperature. The reaction mixture is stirred at ambient temperature for 30 min. The mixture is neutralized with 1 N NaOH aqueous solution and saturated NaHCO3 aqueous solution, extracted with CH2Cl2. The extracts are washed with brine, dried over Na2SO4, and concentrated under reduced pressure to give 160 mg of 2-[4-(4-acetyl-piperazin-1-yl)-phenylamino]-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde as a yellow solid.

Provenance & Evidence