Hydrochloric Acid → HCID 86637347, compound

Participants

Reaction Steps

A mixture of 2-[4-(4-acetyl-piperazin-1-yl)-phenylamino]-7-(1-ethyl-propyl)-7H-pyrrolo[2,3-d]pyrimidine-6-carbaldehyde (25 mg, 0.057 mmol), methoxylamine hydrochloride (20 mg, 0.22 mmol) and 6N HCl (0.03 mL) in EtOH (1 mL) is stirred at ambient temperature for 6 h. The mixture was quenched with saturated NaHCO3 aqueous solution, extracted with CH2Cl2. The extracts were washed with brine, dried over Na2SO4, and concentrated under reduced pressure to give the crude product. The crude product is purified by preparative HPLC to give 12 mg of 1-{4-[4-(7-(1-ethyl-propyl)-6-{1-methoxyimino-ethyl}-7H-pyrrolo[2,3-d]pyrimidin-2-ylamino)-phenyl]-piperazin-1-yl}-ethanone as a bright yellow solid.

Provenance & Evidence