p-Toluenesulfonic acid → HCID 86637353, compound

Participants

Reaction Steps

To a solution of 2-chloro-9-(1-ethyl-propyl)-7,9-dihydro-purin-8-one (0.5 g, 2.3 mmol) in DMF (5 mL) is added triethyl orthoformate (3.8 mL, 23 mmol) and TsOH (0.88 g, 2.6 mmol). The reaction is stirred overnight. The reaction mixture is quenched with ice water and extracted with EtOAc. The extracts are dried over Na2SO4 and concentrated in vacuo. Purification by flash chromatography (SiO2, EtOAC/Hexane 1:3) gives 0.39 g of 2-chloro-9-(1-ethyl-propyl)-9H-purine.

Provenance & Evidence