HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methyl-2-(2-nitrobenzenesulfonylamino)propionamide → 3-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-[(4-{3-(1-carbamoyl-1-(methyl)ethylamino]propoxy}phenyl)methyl]-5-isopropyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methyl-2-(2-nitrobenzenesulfonylamino)propionamide | HCID 23078874 | — |
| Reactant | [(2-Nitrophenylsulfonyl)amino]acetamide | HCID 23078895 | — |
| Reactant | 3-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-{[4-(3-hydroxypropoxy)phenyl]methyl}-5-isopropyl-1H-pyrazole | HCID 68942902 | — |
| Product | 3-(2,3,4,6-Tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-[(4-{3-(1-carbamoyl-1-(methyl)ethylamino]propoxy}phenyl)methyl]-5-isopropyl-1H-pyrazole | HCID 68945326 | — |
Reaction Steps
The title compound was prepared in a similar manner to that described in Example 39 using 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-hydroxypropoxy)phenyl]-methyl}-5-isopropyl-1H-pyrazole and 2-methyl-2-(2-nitrobenzenesulfonylamino)propionamide instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-hydroxypropoxy)-2-methylphenyl]methyl}-5-isopropyl-1H-pyrazole and 2-(2-nitrobenzenesulfonylamino)acetoamide, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324176B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-1b0bd71d110a4f5d92bcc0c30f3ffff2 |
| Source note | uspto-grants-2012_12 |