HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyloxycarbonylglycine → 4-[(4-(3-[(S)-2,5-Diaminopentanoylamino]propoxy)-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyloxycarbonylglycine | HCID 14349 | — |
| Reactant | N2,N5-Bis((phenylmethoxy)carbonyl)-L-ornithine | HCID 7073470 | — |
| Reactant | 3-(2,3,4,6-tetra-O-acetyl-beta-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)-2-methylphenyl]-methyl}-5-isopropyl-1H-pyrazole | HCID 68940120 | — |
| Product | 4-[(4-(3-[(S)-2,5-Diaminopentanoylamino]propoxy)-2-methylphenyl)methyl]-3-(beta-D-glucopyranosyloxy)-5-isopropyl-1H-pyrazole | HCID 68946697 | — |
Reaction Steps
The title compound was prepared in a similar manner to that described in Example 13 using 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)-2-methylphenyl]methyl}-5-isopropyl-1H-pyrazole and (S)-2,5-bis(benzyloxycarbonylamino)pentanoic acid instead of 3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyloxy)-4-{[4-(3-aminopropoxy)phenyl]methyl}-5-isopropyl-1H-pyrazole and 2-benzyloxycarbonylaminoacetic acid, respectively.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324176B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-ff35545068864df6824a4d07310a676e |
| Source note | uspto-grants-2012_12 |