Hydrazine → 1,1-Dimethylethyl 6-chloro-3-hydrazinyl-4-pyridazinecarboxylate

Participants

Reaction Steps

To a solution of tert-butyl 3,6-dichloropyridazine-4-carboxylate (66A) (3.9 g, 15.6 mmol) in EtOH (20 mL) was added anhydrous hydrazine (2 mL). The reaction mixture was stirred at room temperature for 2 h, and then concentrated under reduced pressure. The crude product was triturated with 80% EtOH in H2O to afford 1.58 g (40%) of the title compound as a yellow solid. HPLC/MS (Method B): retention time=1.77 min, [M+H]+=189.3.

Provenance & Evidence