Methyl iodide → HCID 44251386, compound

Participants

Reaction Steps

The tert-butyl-3-(methyl(6-(2-methylpyridine-3-yloxy)pyridine-3-yl)carbamoyl)-1H-indole-1-carboxylate (40 mg, 0.087 mmol) in Example 12 was dissolved in THF (10 ml), and NaH (21 mg, 0.54 mmol) and methyl iodide (0.95 g, 0.67 mmol) were added to the solution. The reaction solution was stirred at room temperature for 5 hours, and then the product was washed and filtered to yield a target compound as a brown solid (20 mg, 12%) by chromatography (methanol:dichloromethane=1:20).

Provenance & Evidence