HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189474Generated: October 29, 2026
Dicyclohexylcarbodiimide → HCID 44250360, compound
https://huagongshe.com/reaction/2189474
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Indole-3-Carboxylic Acid | HCID 69867 | — |
| Reactant | 6-[(Pyrimidin-5-yl)oxy]pyridin-3-amine | HCID 68966106 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44250360 | HCID 44250360 | 59.3% |
Reaction Steps
The 6-(pyrimidine-5-yloxy)-pyridine-3-ylamine (53 mg, 0.28 mmol) and indole-3-carboxylic acid (45 mg, 0.28 mmol) were dissolved in DMF (5 ml), DCC (58 mg, 0.28 mmol) was added to the solution, and then the mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (55 mg, 59%) by chromatography (methanol:dichloromethane=2:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324246B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-55cbf320cb5e4a0f89348d1d7e298d9b |
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| Source note | uspto-grants-2012_12 |
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