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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189474Generated: October 29, 2026

Dicyclohexylcarbodiimide → HCID 44250360, compound

https://huagongshe.com/reaction/2189474

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantIndole-3-Carboxylic AcidHCID 69867—
Reactant6-[(Pyrimidin-5-yl)oxy]pyridin-3-amineHCID 68966106—
SolventDimethylformamideHCID 6228—
ProductHCID 44250360HCID 4425036059.3%

Reaction Conditions

Temperature80 °C

Reaction Steps

The 6-(pyrimidine-5-yloxy)-pyridine-3-ylamine (53 mg, 0.28 mmol) and indole-3-carboxylic acid (45 mg, 0.28 mmol) were dissolved in DMF (5 ml), DCC (58 mg, 0.28 mmol) was added to the solution, and then the mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (55 mg, 59%) by chromatography (methanol:dichloromethane=2:30).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324246B2
Source datasetuspto-grants-2012_12
ORD IDord-55cbf320cb5e4a0f89348d1d7e298d9b
Source noteuspto-grants-2012_12