HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189476Generated: October 30, 2026
Dicyclohexylcarbodiimide → HCID 44250362, compound
https://huagongshe.com/reaction/2189476
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Indole-3-Carboxylic Acid | HCID 69867 | — |
| Reactant | 6-[(6-Methyl-3-pyridinyl)oxy]-3-pyridinamine | HCID 18005166 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44250362 | HCID 44250362 | 66.3% |
Reaction Steps
The 6-(6-methylpyridine-3-yloxy)-pyridine-3-amine (300 mg, 1.49 mmol) and indole-3-carboxylic acid (240 mg, 1.49 mmol) were dissolved in DMF (10 ml), DCC (280 mg, 1.49 mmol) was added to the solution, and then the mixture was stirred at 80° C. for 3 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a grey solid (340 mg, 66%) by chromatography (methanol:dichloromethane=1:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324246B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-8b76756a08434973ab62d08af47e6106 |
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| Source note | uspto-grants-2012_12 |
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