HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189479Generated: October 30, 2026
Dicyclohexylcarbodiimide → HCID 44250364, compound
https://huagongshe.com/reaction/2189479
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dicyclohexylcarbodiimide | HCID 10868 | — |
| Reactant | Indole-3-Carboxylic Acid | HCID 69867 | — |
| Reactant | Pyridine, 5-amino-2,3'-oxydi- | HCID 2800156 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44250364 | HCID 44250364 | 61% |
Reaction Steps
The 6-(pyridine-3-yloxy)pyridine-3-amine (200 mg, 1.24 mmol) and indole-3-carboxylic acid (200 mg, 1.24 mmol) were dissolved in DMF (5 ml), DCC (280 mg, 1.37 mmol) was added to the solution, and then the mixture was stirred at 60° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (250 mg, 61%) by chromatography (methanol:dichloromethane=1:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324246B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-6ade59d2d1004b16bac8a0252c45ce0b |
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| Source note | uspto-grants-2012_12 |
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