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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189479Generated: October 30, 2026

Dicyclohexylcarbodiimide → HCID 44250364, compound

https://huagongshe.com/reaction/2189479

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantIndole-3-Carboxylic AcidHCID 69867—
ReactantPyridine, 5-amino-2,3'-oxydi-HCID 2800156—
SolventDimethylformamideHCID 6228—
ProductHCID 44250364HCID 4425036461%

Reaction Conditions

Temperature60 °C

Reaction Steps

The 6-(pyridine-3-yloxy)pyridine-3-amine (200 mg, 1.24 mmol) and indole-3-carboxylic acid (200 mg, 1.24 mmol) were dissolved in DMF (5 ml), DCC (280 mg, 1.37 mmol) was added to the solution, and then the mixture was stirred at 60° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (250 mg, 61%) by chromatography (methanol:dichloromethane=1:30).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324246B2
Source datasetuspto-grants-2012_12
ORD IDord-6ade59d2d1004b16bac8a0252c45ce0b
Source noteuspto-grants-2012_12