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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2189482Generated: October 29, 2026

Dicyclohexylcarbodiimide → HCID 44250433, compound

https://huagongshe.com/reaction/2189482

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDicyclohexylcarbodiimideHCID 10868—
ReactantIndole-3-Carboxylic AcidHCID 69867—
Reactant3-(Pyridin-3-yl)anilineHCID 459521—
SolventDimethylformamideHCID 6228—
ProductHCID 44250433HCID 4425043355%

Reaction Conditions

Temperature80 °C

Reaction Steps

The crude 3-pyridine-3-yl-phenylamine (60 mg, 0.35 mmol) and indole-3-carboxylic acid (57 mg, 0.35 mmol) were dissolved in DMF (3 ml), DCC (73 mg, 0.35 mmol) was added to the solution, and then the mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (60 mg, 55%) by chromatography (methanol:dichloromethane=1:20).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08324246B2
Source datasetuspto-grants-2012_12
ORD IDord-4c58df97a81f4524a4d10d510a333e06
Source noteuspto-grants-2012_12