Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 6-Methyl-1H-indole-3-carboxylic acid | HCID 18385211 | — |
| Reactant | 6-[(2-Chloro-3-pyridinyl)oxy]-3-pyridinamine | HCID 87638734 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 44250434 | HCID 44250434 | 34% |
Reaction Steps
The 6-methyl-1H-indole-3-carboxylic acid (50 mg, 0.28 mmol) in Example 16 and the 6-(2-chloropyridine-3-yloxy)-pyridine-3-amine (60 mg, 0.28 mmol) in Example 22 were dissolved in DMF (5 ml), HBTU (100 mg, 0.28 mmol) and triethylamine (0.11 ml, 0.84 mmol) were added to the solution, and the mixture was stirred at 80° C. for 8 hours. After the reaction was completed, the product was washed and filtered to yield a target compound as a white solid (18 ml, 34%) by chromatography (methanol:dichloroinethane=1:30).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08324246B2 |
|---|
| Source dataset | uspto-grants-2012_12 |
|---|
| ORD ID | ord-14951823e35741b0847ff7507ce37e6e |
|---|
| Source note | uspto-grants-2012_12 |
|---|
