6-Chloropyridine-2-carbonitrile → HCID 44629396, compound

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Reaction Steps

1′-(3-Trifluoromethylbenzenesulfonyl)-1′,2′,3′,6′-tetrahydro-[2,4′]bipyridinyl-6-carbonitrile (32) was synthesized similarly to compound 7 in Example 1 starting with 2-chloro-6-cyanopyridine (22) instead of compound 1. 1H NMR (400 MHz, CD3OD): δ 8.15 (d, 1H, J=8.4 Hz), 8.12 (s, 1H), 8.00 (d, 1H, J=7.6 Hz), 7.92 (m, 1H), 7.86 (m, 1H), 7.80 (m, 1H), 7.70 (m, 1H), 6.76 (m, 1H), 3.93 (m, 2H), 3.43 (m, 2H), 2.73 (m, 2H); MS: 394 (M+H+).

Provenance & Evidence