3-(Trifluoromethyl)benzenesulfonyl chloride → HCID 44628179, compound

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Reaction Steps

Similarly, 5-chloro-1′-(4-trifluoromethoxybenzenesulfonyl)-1′,2′,3′,6′-tetra-hydro-[2,4′]bipyridinyl-6-carboxylic acid cyclopropylamide was synthesized using 4-trifluoromethoxybenzenesulfonyl chloride at the last step instead of 3-trifluoromethylbenzenesulfonyl chloride. 1H NMR (400 MHz, CD3OD): δ 7.99 (m, 2H), 7.85 (d, 1H, J=8.4 Hz), 7.59 (d, 1H, J=8.4 Hz), 7.54 (m, 2H), 6.72 (m, 1H), 3.87 (m, 2H), 3.39 (t, 2H, J=5.6 Hz), 2.87 (m, 1H), 2.73 (m, 2H), 0.83 (m, 2H), 0.66 (m, 2H); MS: 502 (M+H+).

Provenance & Evidence