HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 1H-Indazole-5-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 5-Cyano-2-fluorobenzaldehyde | HCID 10909725 | — |
| Product | 1H-Indazole-5-carbonitrile | HCID 11126384 | — |
Reaction Steps
2-fluoro-5-cyanobenzaldehyde (1.1 g) is dissolved in hydrazine hydrate (19 ml) and stirred at room temperature for 18 hours. The solution is then distilled and the residue purified by flash column chromatography on silica, eluting with DCM. This gives the title compound (300 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324254B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-d10481a21fe3425bbb45c19dd6a9df86 |
| Source note | uspto-grants-2012_12 |