反应详情

To a stirred suspension of Methyl 3-chloro-4-(ethyloxy)benzoate (D6) (11.24 g, 52.4 mmol) in methanol (40 ml) was added 2M aq. NaOH (40 ml) and the resultant mixture was heated at 60° C. for 2 hours. The reaction mixture was partitioned between EtOAc and dilute hydrochloric acid. The organics were separated, dried and evaporated in vacuo to give the crude product. This material was triturated with ether to give the title compound as a white solid (8.21 g). MS (ES): C9H935ClO3 requires 200; found (MH+) 201.

1. customThe reaction mixture was partitioned between EtOAc and dilute hydrochloric acid
2. customThe organics were separated
3. customdried
4. customevaporated in vacuo
5. customto give the crude product
6. customThis material was triturated with ether