HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-(1-Cyclohexen-1-yl)-3-(trifluoromethyl)benzamide → 4-Cyclohexyl-3-(trifluoromethyl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-(1-Cyclohexen-1-yl)-3-(trifluoromethyl)benzamide | HCID 59201828 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-Cyclohexyl-3-(trifluoromethyl)benzamide | HCID 59201794 | 95.9% |
Reaction Steps
4-(1-Cyclohexen-1-yl)-3-(trifluoromethyl)benzamide (D32) (850 mg, 3.16 mmol) was dissolved in methanol (63 ml) and hydrogenated using an H-Cube, using palladium on carbon at 40° C. with a flow rate of 2 mL/min. The solvent was removed in vacuo to give the title compound as a white solid (822 mg). MS (ES): C14H16F3NO requires 271; found 272 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324254B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-9aaee2c39372469aad834e8d62aced5b |
| Source note | uspto-grants-2012_12 |