HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl bromoacetate → Ethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl bromoacetate | HCID 7748 | — |
| Reactant | 5-[3-(1H-indazol-5-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile | HCID 53247367 | — |
| Product | Ethyl [5-(5-{3-cyano-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]acetate | HCID 59316757 | — |
Reaction Steps
Prepared in a similar fashion to (D44) from 5-[3-(1H-indazol-5-yl)-1,2,4-oxadiazol-5-yl]-2-[(1-methylethyl)oxy]benzonitrile (D43) and ethyl bromoacetate. The crude material was purified by trituration with diethyl ether to give the title compound as a yellow solid. MS (ES) C23H21N5O4 requires 431; found (MH+) 432.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324254B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-26b56bef472040d095df1b77b9ec8d73 |
| Source note | uspto-grants-2012_12 |