反应详情

Ethyl 3-[5-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]propanoate (D5) (1.95 g, 4.29 mmol) was dissolved in ethanol. 2M NaOH (2.143 ml, 4.29 mmol) was added and the solution was stood at R.T. for 3 hours. Ethanol was evaporated and the mixture was dissolved in EtOAc and water and acidified with acetic acid. Organic layer was dried (MgSO4) and evaporated to give (1.34 g) of white solid. δH (d6-DMSO, 400 MHz): 1.37 (6H, d), 2.89 (2H, t), 4.65 (2H, t), 4.89 (1H, m), 7.45 (1H, d), 7.89 (1H, d), 8.06 (1H, d), 8.12 (1H, d), 8.20 (1H, s), 8.27 (1H, s), 8.55 (1H, s). MS (ES): C21H1935ClN4O4 requires 426; found 427 (MH+).

1. customEthanol was evaporated
2. dissolutionthe mixture was dissolved in EtOAc
3. dry with materialOrganic layer was dried (MgSO4)
4. customevaporated