反应详情

Ethyl 3-(5-{5-[4-[(1-methylethyl)oxy]-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-3-yl}-1H-indazol-1-yl)propanoate (D59) (82 mg, 0.17 mmol) was dissolved in ethanol (4 ml) and then 2M aq. NaOH added (0.5 ml). The reaction was stirred at room temperature overnight and then the ethanol was evaporated in vacuo. Ethyl acetate was added but as the compound appeared to be in both aqueous and organic layers the mixture was evaporated. Purification by MDAP (in two batches) followed by freeze-drying gave the title compound (28.7 mg). δH (400 MHz, d6-DMSO) 1.36 (6H, d), 2.88 (2H, t), 4.65 (2H, t), 4.98 (1H, sept.), 7.59 (1H, d), 7.89 (1H, d), 8.07 (1H, dd), 8.27 (1H, d), 8.32 (1H, d), 8.41 (1H, dd), 8.57 (1H, dd). MS (ES): C22H19F3N4O4 requires 460; found (MH+) 461.

1. customthe ethanol was evaporated in vacuo
2. additionEthyl acetate was added but as the compound
3. customwas evaporated
4. customPurification by MDAP (in two batches)
5. customby freeze-drying