Sodium Hydroxide → HCID 25062824, compound

Participants

Reaction Conditions

Reaction Steps

2M Sodium hydroxide (1 ml, 2 mmol) was added to a solution of ethyl 4-[4-(5-{3-chloro-4-[(1-methylethyl)oxy]phenyl}-1,2,4-oxadiazol-3-yl)-1H-indazol-1-yl]butanoate (D60) (N2666-13-A1) (0.062 g, 0.132 mmol) in ethanol (5 ml) and the reaction was heated to 80° C. to effect dissolution then left to cool for 2 hours. Evaporated, dissolved in ethyl acetate/water (25 ml of each) and acidified with acetic acid. Organic dried (magnesium sulphate), evaporated, azeotroped with 15 ml of toluene and triturated with ether. Filtered to give the title compound (42 mg) as a white solid. 5H (d6-DMSO, 400 MHz): 1.37 (6H, d), 2.09 (2H, m), 2.24 (2H, t), 4.54 (2H, t), 4.90 (1H, m), 7.47 (1H, d), 7.62 (1H, dd), 7.97 (1H, d), 8.01 (1H, d), 8.17 (1H, dd), 8.26 (1H, d), 8.56 (1H, s). MS (ES): C22H2135ClN4O4 requires 440; found (MH+) 441.

Provenance & Evidence