HCID 16203217, compound → HCID 16203218, compound

Participants

Reaction Steps

A mixture of (174) (0.370 mg, 0.86 mmol) and 5% Pd—C (10 mg) in ethyl acetate (20 mL) was stirred under a hydrogen atmosphere for 20 h and then filtered though the pad of celite. The celite was then washed sequentially with ethyl acetate and acetic acid. The combined filtrates were concentrated. The solid obtained was recrystallized from ethyl acetate to give (175) (0.185 g, 63%): mp 240-41° C., 1H NMR (400 MHz, d6-DMSO-CDCl3): δ 0.99-1.11 (m, 1H), 1.72-1.76 (m, 1H), 2.43 (s, 3H), 2.67-2.83 (m, 2H), 3.46-3.53 (m, 1H), 3.87 (s, 3H), 5.61 (d, J=10.8 Hz, 1H), 6.74 (d, J=8.4 Hz, 2H), 6.87 (d, J=8.8 Hz, 2H), 6.61 (m, 1H), 7.07 (d, J=8.4 Hz, 1H), 7.43-7.46 (m, 1H), 7.52 (d, J=3.2 Hz, 1H). Anal. (C20H20N2O3) C, H, N.

Provenance & Evidence