HCID 1070510, compound → HCID 16203557, compound

Participants

Reaction Steps

To the solution of (141) (180 mg, 0.51 mmol) in THF (5 mL) was added LiAlH4 (2.056 mL, 2.056 mmol; 1M in THF) at room temperature. The reaction mixture was stirred at room temperature for 1 h and then quenched with methanol followed by ice. The reaction mixture was extracted with ethyl acetate. Organic layer was washed with water, dried over anhydrous sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel using 25% ethyl acetate-hexane as eluent to give (157) (30 mg, 17%): thick oil, 1H NMR (500 MHz, CDCl3): δ 1.40 (t, J=7.0 Hz, 3H), 1.72-2.04 (m, 2H), 2.62-2.85 (m, 2H), 3.87 (s, 6H), 4.15 (q, J=7.0 Hz, 2H), 4.75 (d, J=10.5 Hz, 1H), 6.75-6.77 (dd, J=8.0 and 3.0 Hz, 1H), 7.01 (d, J=8.0 Hz, 2H), 7.12 (d, J=8.5 Hz, 1H), 7.29 (d, J=8.0 Hz, 2H), 7.44 (d, J=3.0 Hz, 1H). LRMS m/z 336.3 (calc for C21H24N2O2, M+, 336.2).

Provenance & Evidence