1,2-Dichloroethane → 4-(4-fluoro-phenyl)-4-[(S)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

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Reaction Steps

4-(4-Fluoro-phenyl)-piperidine-1,4-dicarboxylic acid mono-tert-butyl ester (1.0 g, 3.092 mmol) (commercially available) was suspended in dichloromethane (10 mL). EDC (949 mg, 4.948 mmol), HOBT (758 mg, 4.948 mmol) and triethylamine (1.6 mL, 11.442 mmol) were added at room temperature, followed by slow addition of a solution of (S-)-1-(4-fluorophenyl)ethylamine (0.50 mL, 3.711 mmol) in dichloromethane (5 mL). The reaction mixture was stirred at room temperature for 12 h. Water was added to the reaction mixture, the aqueous phase was extracted with ethyl acetate, the organic layers were combined and washed with aqueous ammonium chloride solution and brine, dried over Na2SO4 and the solvents were evaporated. The residue was purified by flash chromatography over a 70 g silica gel column with n-heptane and ethyl acetate to give 735 mg 4-(4-fluoro-phenyl)-4-[(S)-1-(4-fluoro-phenyl)-ethylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester. MS ISN (m/e): 433.7 [(M−H)−].

Provenance & Evidence