tert-Butyl Formate → 1'-tert-butyl 5-ethyl Spiro[indoline-3,4'-piperidine]-1',5-dicarboxylate

HRID 2190015Notes

Reaction equation

HRID 2190015 reaction equation
[N:1]1([C:20]([O:22][C:23]([CH3:26])([CH3:25])[CH3:24])=[O:21])[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=3)[N:8]=[CH:7]2)[CH2:3][CH2:2]1.C(OC(C)(C)C)=O>>[N:1]1([C:20]([O:22][C:23]([CH3:24])([CH3:26])[CH3:25])=[O:21])[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[C:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH:13]=3)[NH:8][CH2:7]2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 61207tert-Butyl FormateHCID 687615391'-Tert-butyl 5-ethyl spiro[indole-3,4'-piperidine]-1',5-dicarboxylate

Product 1

HCID 698121951'-tert-butyl 5-ethyl Spiro[indoline-3,4'-piperidine]-1',5-dicarboxylate

Procedure

1′-tert-butyl 5-ethyl Spiro[indoline-3,4′-piperidine]-1′,5-dicarboxylate was prepared by the procedures described in Example 1, Step 2, substituting tert-butyl 5-chloro spiro[indole-3,4′-piperidine]-1′-carboxylate with 1′-tert-butyl 5-ethyl spiro[indole-3,4′-piperidine]-1′,5-dicarboxylate. LCMS (APCI+) m/z 261.3 [M+H-Boc]+; Rt=3.76 min.

Sources & evidence

ORD record
ord-42d1683c1792497e990cde4a7f96cd76
Source dataset
uspto-grants-2012_12
Patent number
US08324221B2

Reaction notes

Loading…