Methanamine, N-methoxy-, hydrochloride (1:1) → HCID 86651805, compound

Participants

Reaction Steps

(3S,5′S)-tert-butyl 5′-(methoxy(methyl)carbamoyl)-2-oxospiro[indoline-3,3′-pyrrolidine]-1′-carboxylate was prepared by the procedures described in Example 10, Step 5, substituting (R)-2-(1′-(tert-butoxycarbonyl)-1-(5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)spiro[indoline-3,4′-piperidine]-5-yl)acetic acid with (3S,5′S)-1′-(tert-butoxycarbonyl)-2-oxospiro[indoline-3,3′-pyrrolidine]-5′-carboxylic acid, and substituting NH4Cl with N,O-dimethylhydroxylamine hydrochloride. LCMS (APCI+) m/z 376 [M+H]+; Rt=2.88 min.

Provenance & Evidence