3-Fluoro-p-anisaldehyde → HCID 68617947, compound

Participants

Reaction Steps

A mixture of 1.33 g of indole-2-one (10 mmol), 1.54 g of 3-fluoro-4-methoxybenzaldehyde (10 mmol) and 3 drops of piperidine are refluxed in 40 ml of ethanol for 5 hours. The desired product precipitates as a yellow crystalline solid during the reaction. After cooling to room temperature, the product is filtered off, washed with ethanol and dried in vacuo. Yield 2.2 g (82%).

Provenance & Evidence