HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylate → Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromo-5-(4-fluorophenyl)furan-2-carboxylate | HCID 58064766 | — |
| Reactant | Ethyl 4-(3-chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylate | HCID 58064795 | — |
| Product | Ethyl 4-(3-chlorophenyl)-5-(4-fluorophenyl)furan-2-carboxylate | HCID 58064804 | — |
Reaction Steps
The synthesis of the title compound takes place in analogy to the synthesis of the compound from Example 11A starting with the compound from Example 7A. Extraction is carried out with dichloromethane and purification with the mobile phase cyclohexane/ethyl acetate (30:1). 4.12 g (41% of theory) of the title compound with a purity of 50% are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-a1905e68fcb840e5a4eebf8afbb13c80 |
| Source note | uspto-grants-2012_12 |