HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate → 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 4-bromo-5-(3-chlorophenyl)furan-2-carboxylate | HCID 58064772 | — |
| Reactant | 4-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid | HCID 58064798 | — |
| Product | 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid | HCID 58064797 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 20A starting with the compound from Example 5A. Instead of using ethyl acetate, the crude product is extracted with dichloromethane and reacted further without chromatographic purification. 447 mg (98% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-99678ff6324c49449c7f0cf733311f55 |
| Source note | uspto-grants-2012_12 |