HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | PyBOP | HCID 2724699 | — |
| Reactant | 4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one | HCID 58064764 | — |
| Reactant | 4-Bromo-5-(3-chlorophenyl)furan-2-carboxylic acid | HCID 58064797 | — |
| Product | 1-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one | HCID 58064783 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 24A and the compound from Example 35A. 1.1 equivalents of PyBOP and 2.5 equivalents of N,N-diisopropylethylamine are used. During the reaction, the product precipitates. The precipitate is collected by suction filtration, washed with tetrahydrofuran and dried under high vacuum. 870 mg (71% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-face59e24ca947948473f00ce2f18566 |
| Source note | uspto-grants-2012_12 |