HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → 1-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-carboxylic acid | HCID 58064761 | — |
| Reactant | 4-{[4-Bromo-5-(3-chlorophenyl)furan-2-yl]carbonyl}piperazin-2-one | HCID 58064764 | — |
| Product | 1-{[5-Bromo-4-(3-chloro-5-fluorophenyl)furan-2-yl]carbonyl}imidazolidin-4-one | HCID 58064778 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 27A starting with the compound from Example 23A and the compound from Example 35A. 5 equivalents of N,N-diisopropylethylamine are used. The product is precipitated by the addition of water to the reaction solution. The precipitate is collected by suction filtration, washed with tetrahydrofuran and dried under high vacuum. 587 mg (97% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-c78b9f9c63f1415fb41298c3e447049b |
| Source note | uspto-grants-2012_12 |