HuagongsheHuagongshe Chemistry Print Report · For research reference only
m-Chloroperbenzoic acid → 3-{3-(3-Chloro-5-fluorophenyl)-5-[(1,1-dioxido-1,3-thiazolidin-3-yl)carbonyl]furan-2-yl}benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | m-Chloroperbenzoic acid | HCID 70297 | — |
| Reactant | 3-[3-(3-Chloro-5-fluorophenyl)-5-(1,3-thiazolidin-3-ylcarbonyl)furan-2-yl]benzenecarbonitrile | HCID 46832300 | — |
| Reactant | 3-{3-(3-Chloro-5-fluorophenyl)-5-[(1-oxido-1,3-thiazolidin-3-yl)carbonyl]furan-2-yl}benzenecarbonitrile | HCID 46832584 | — |
| Product | 3-{3-(3-Chloro-5-fluorophenyl)-5-[(1,1-dioxido-1,3-thiazolidin-3-yl)carbonyl]furan-2-yl}benzenecarbonitrile | HCID 46832586 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 3 starting with the compound from Example 1. Instead of 1.0 equivalent of meta-chloroperbenzoic acid, 2.2 equivalents are used. 80.0 mg (78% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-69a7bef0e3ff4d4fb6a5263df76a802b |
| Source note | uspto-grants-2012_12 |