HuagongsheHuagongshe Chemistry Print Report · For research reference only
Piperazin-2-one → 3-{3-(3-Chloro-5-fluorophenyl)-5-[(3-oxopiperazin-1-yl)carbonyl]furan-2-yl}benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Piperazin-2-one | HCID 231360 | — |
| Reactant | 4-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid | HCID 58064798 | — |
| Reactant | 4-{[4-(3-Chlorophenyl)-5-(4-fluorophenyl)furan-2-yl]carbonyl}piperazin-2-one | HCID 58064800 | — |
| Product | 3-{3-(3-Chloro-5-fluorophenyl)-5-[(3-oxopiperazin-1-yl)carbonyl]furan-2-yl}benzenecarbonitrile | HCID 46832588 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 6 starting with the compound from Example 20A. Instead of 1.5 equivalents of piperazin-2-one, 1.1 equivalents are used. 55.0 mg (89% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-818b0ddb6c9542a9ad9092a60f228e55 |
| Source note | uspto-grants-2012_12 |