HuagongsheHuagongshe Chemistry Print Report · For research reference only
(R)-3-Pyrrolidinol → 3-[3-(3-Chloro-5-fluorophenyl)-5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}furan-2-yl]benzenecarbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (R)-3-Pyrrolidinol | HCID 2759337 | — |
| Reactant | 4-(3-Chloro-5-fluorophenyl)-5-(3-cyanophenyl)furan-2-carboxylic acid | HCID 58064798 | — |
| Reactant | 4-{[4-(3-Chlorophenyl)-5-(4-fluorophenyl)furan-2-yl]carbonyl}piperazin-2-one | HCID 58064800 | — |
| Product | 3-[3-(3-Chloro-5-fluorophenyl)-5-{[(3R)-3-hydroxypyrrolidin-1-yl]carbonyl}furan-2-yl]benzenecarbonitrile | HCID 46832878 | — |
Reaction Steps
The preparation of the title compound takes place in analogy to the synthesis of the compound from Example 6 starting with the compound from Example 20A. 1.1 equivalents of (3R)-pyrrolidin-3-ol are used. 51.0 mg (85% of theory) of the title compound are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08324268B2 |
| Source dataset | uspto-grants-2012_12 |
| ORD ID | ord-4215eaa9ba2147d499946e84d12cd0f6 |
| Source note | uspto-grants-2012_12 |