反应详情

The methyl 5-(N-(5-iodo-3-(methylcarbamoyl)-2-p-tolylfuro[2,3-b]pyridin-6-yl)methylsulfonamido)pentanoate (35 mg, 0.058 mmol) was suspended/dissolved in 1 mL toluene and added to 2. 1 was added to 2. The biphasic mixture was degassed for 5 min, then microwaved at 122° C. for 10 min. The mixture was then heated again at the same temperature for another 2×10 min. HPLC purification yielded methyl 5-(N-(5-cyclopropyl-3-(methylcarbamoyl)-2-p-tolylfuro[2,3-b]pyridin-6-yl)methylsulfonamido)pentanoate (20 mg, 0.039 mmol, 67%) MS-ES [M+H]+=513.9, LC RT=1.60 min, Method A.

1. additionadded to 2
2. addition1 was added to 2
3. customThe biphasic mixture was degassed for 5 min
4. custommicrowaved at 122° C. for 10 min
5. temperatureThe mixture was then heated again at the same temperature for another 2×10 min
6. customHPLC purification