Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 2190173생성일: 2026년 10월 27일
Dimethylformamide → 2-(4-Fluoro-phenyl)-5-iodo-6-(methanesulfonyl-pent-4-enyl-amino)-furo[2,3-b]pyridine-3-carboxylic acid methylamide
https://huagongshe.com/reaction/2190173
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylformamide | HCID 6228 | — |
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 1-Pentene, 5-bromo- | HCID 70704 | — |
| 반응물 | 2-(4-fluorophenyl)-5-iodo-N-methyl-6-(methylsulfonamido)furo[2,3-b]pyridine-3-carboxamide | HCID 58052324 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2-(4-Fluoro-phenyl)-5-iodo-6-(methanesulfonyl-pent-4-enyl-amino)-furo[2,3-b]pyridine-3-carboxylic acid methylamide | HCID 58052328 | 55% |
반응 단계
A mixture of 2-(4-fluorophenyl)-5-iodo-N-methyl-6-(methylsulfonamido)furo[2,3-b]pyridine-3-carboxamide (440 mg), Cs2CO3 (322 mg, 1.1 eq.), 5-bromopent-1-ene (402 mg, 3 eq.) and dry DMF (4.5 ml) was stirred in a microwave reactor at 150° C. for 15 min and cooled to rt. Water was added and the mixture was extracted with methylene chloride. The organic layer was washed with 2× water. Silica gel flash chromatography using 0-11% ether-methylene chloride yielded the title compound (250 mg, 55%). MS (ESI) m/z 558.1 (M+1). Retention time=1.33 min (Method A).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08324239B2 |
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| 출처 데이터셋 | uspto-grants-2012_12 |
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| ORD ID | ord-98dff851b12c432d8533cd24f9f5677f |
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| 출처 메모 | uspto-grants-2012_12 |
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