Potassium Carbonate → 2-(4-fluorophenyl)-N-methyl-6-(methylsulfonamido)-5-(prop-1-en-2-yl)furo[2,3-b]pyridine-3-carboxamide

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Reaction Conditions

Reaction Steps

To prop-1-en-2-ylmagnesium bromide (0.5 M THF solution, 6.1 ml, 5 eq.) in a heatgun-dried microwave tube at 0° C. was added triisopropyl borate (0.71 ml, 5 eq.). The mixture was stirred at 0° C. for 15 min and warmed to rt. K2CO3 (2 M aq. solution, 1.5 ml, 5 eq.) was added. The mixture was stirred at rt for 15 min. 2-(4-Fluorophenyl)-5-iodo-N-methyl-6-(methylsulfonamido)furo[2,3-b]pyridine-3-carboxamide (300 mg, 1 eq.) and Pd(PPh3)4 (106 mg, 0.15 eq.) were added. The mixture was degassed, stirred in a microwave reactor at 120° C. for 20 min and cooled. Water was added followed by LiOH (1 M aq. solution, 1.8 ml). The mixture was washed with ether. (It took a long time for layers to settle. There may be a solid meta-phase which can be filtered out as pure product.) Aq. layer was acidified to pH 3.5 using saturated citric acid. Precipitate was filtered, washed with water and lyophilized to give the title compound as an off-white solid (180 mg, 73%). MS (ESI) m/z 404.2 (M+1). Retention time=1.23 min (Method A).

Provenance & Evidence