HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2190180Generated: October 31, 2026
HCID 58052458, compound → HCID 58052525, compound
https://huagongshe.com/reaction/2190180
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | HCID 58052458 | HCID 58052458 | — |
| Catalyst | (1,3-Bis(2,4,6-trimethylphenyl)imidazolidin-2-ylidene)(dichloro)((2-((propan-2-yl)oxy)phenyl)methylidene)ruthenium | HCID 11763533 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 58052525 | HCID 58052525 | — |
Reaction Steps
A mixture of 2-(4-fluorophenyl)-N-methyl-6-(N-(pent-4-enyl)methylsulfonamido)-5-vinylfuro[2,3-b]pyridine-3-carboxamide (5.0 mg, 1 eq.), Hoveyda-Grubbs catalyst 2nd generation (0.7 mg, 0.1 eq.) and methylene chloride (0.55 ml) was degassed and stirred in a microwave reactor at 100° C. for 15 min. The reaction mixture was diluted with EtOAc, filtered through a 0.2 μM PTFE syringe filter and concentrated to yield the crude title compound which was used without purification in the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US08324239B2 |
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| Source dataset | uspto-grants-2012_12 |
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| ORD ID | ord-fb39f7e19d25486096120dae882af0a8 |
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| Source note | uspto-grants-2012_12 |
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