Sodium Iodide → HCID 58052428, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 5-cyclopropyl-6-methanesulfonylamino-2-p-tolyl-furo[2,3-b]pyridine-3-carboxylic acid methylamide (900 mg, 2.25 mmol, 1.0 equiv) in DMA (2.0 mL) was added NaI (169 mg, 1.12 mmol, 0.5 equiv) and Cs2CO3 (2.2 g, 6.76 mmol, 3.0 equiv) and the resulting mixture was heated at 110° C. for 1 hour. The mixture was then diluted with EtOAc and washed with water, brine, dried over MgSO4 and concentrated. The residue wad purified by silica gel column chromatography, EtOAc/heptane (70%) to give product 760 mg. MS (ESI) m/z 454.5 (M+1). Retention time=1.58 min, Method LC-C8 broad range-NpH.

Provenance & Evidence